SETOX

Slovak Toxicology Society

What is our main purpose?
IN VITRO tests in the field of education

 

Important books

Viabilita, proliferácia a smrť buniek kultivovaných v in vitro podmienkach
Viability, proliferation and cell death cultivated in vitro [in Slovak]
ISBN 978-80-227-3111-9
60 pages, 33 pictures, 6 tables
Publisher: Slovak University of Technology, Bratislava, 2009

Author:
Assoc Prof. Soňa Jantová, PhD.
The Faculty of Chemical and Food Technology in Bratislava (Slovakia)
e-mail: sona.jantova@stuba.sk

cell_viability

The Three Rs and the Humanity Criterion
An abridged version od The Principles of Humane Experimental Technique by WMS Russell and RL Burch
ISBN 978-0-9501700-2-2
131 pages
Publisher: Fund for the Replacement of Animals in Medical Experiments, 2009

Author:

Michael Balls

RRR

DRUG DISCOVERY TOXICOLOGY

Editors: Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy
ISBN: 978-1-119-05333-0 (e-book), Wiley,  Apr 2016, 584 pages
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process.
• Guides researchers as to what drug safety experiments are both practical and useful
• Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools
• Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods
• Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Contributing members of SETOX: Dr. Helena Kandarova (Chapter 12)

 

 

VALIDATION OF ALTERNATIVE METHODS FOR TOXICITY TESTING

Editors: Chantra Eskes, Maurice Whelan
ISBN 978-3-319-33826-2, Springer, 2016, 399 pages

This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology.
Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment.
This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.

 

ALTERNATIVES FOR DERMAL TOXICITY TESTING

Editors: Chantra Eskes, Erwin van Vliet, Erwin, Howard I. Maibach
ISBN 978-3-319-50353-0 (e-book), ISBN 978-3-319-50351-6 (book), Springer, 2017 592 pages

This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.
Contributing members of SETOX: Dr. Helena Kandarova (Chapters 3, 9 and 35)


WHAT's NEW?

EUROTOX 2018 Meeting will be organized by the Belgian Society of Toxicology and Ecotoxicology (BelTox) from 2 to 5 September, 2018, in Brussels.

TOXCON 2018 will be organized by SETOX in High Tatras on June 20 – 22. First announcement will be available in January 2018. Information about TOXCON 2018 meeting will be soon uploaded here: http://www.toxcon.sav.sk/

 

Important links

EUROTOX Information about toxicology in EU

Go3R - Search engine for alternative methods

IEPT SASc Institute of Experimental Pharmacology & Toxicology

VERSITA online publishing

EDUCATION

Application for fellowships for ERT courses in 2018
EUROTOX is pleased to once again offer the opportunity to apply for fellowships to attend comprehensive training courses in toxicology (ERT courses), and for cross-border exchange of teachers on such courses. The deadline for applications concerning the first half of 2018 is 15 December 2017.

Full details regarding eligibility and application process can be found here (for course attendees) and here (for teachers)

Note New Deadlines for applications:

15 December 2017 for courses between 1 January and 30 June 2018

31 May 2018 for courses between 1 July and 31 December 2018

For more information, please contact fellowships@eurotox.com

 

ESTIV Applied In Vitro Toxicology Course
Course if taking place April 8-13, 2018 at Utrecht University's campus, Utrecht, the Netherlands. The course is organised by the European Society of Toxicology In Vitro (ESTIV) and the Dutch Society of Toxicology (NVT) http://estivnvt2018.webs.com

Main goals of the Society

To support cooperation and exchange of information between SETOX and international professional organizations

To support research and development in the field of toxicology

To propose toxicological projects of research and development

To support participation of members in activities at international platform

Interdisciplinary Toxicology
Interdisciplinary Toxicology
The Official Journal of the SETOX