EDITORIAL

P. Anzenbacher and E. Anzenbacherová
Enzyme Systems of Detoxication – Overview of Recent Approaches

M. Stiborová, J. Hudeček, E. Frei and H.H. Schmeiser
Contribution of Biotransformation Enzymes to the Development of Renal Injury and Urothelial Cancer Caused by Aristolochic Acid: Urgent Questions, Difficult Answers

E. Horváthová
Trends in the Study of Genetic Susceptibility

M. Tichý, I. Hanzlíková, M. Rucki, A. Pokorná, R. Uzlová, J. Tumová
Acute Toxicity of Binary Mixtures: Alternative Methods, QSAR and Mechanisms

J. Kassa, J. Bajgar, K. Kuča, K. Musílek, J. Karasová
The Present Approaches to the Development of Prophylactic and Therapeutic Antidotes Against Nerve Agents

A. Korkmaz, D.X. Tan and R.J. Reiter
Acute and Delayed Sulfur Mustard Toxicity; Novel Mechanisms and Future Studies

E. Ujházy, J. Navarová, M. Dubovický, Š. Bezek, M. Mach
Important Issues in Developmental Toxicity Testing

Š. Bezek, E. Ujházy, M. Mach, J. Navarová, M. Dubovický
Developmental Origin of Chronic Diseases: Toxicological Implication

ABSTRACTS from 13th Interdisciplinary Toxicology Conference TOXCON 2008 - Trenčianske Teplice
(A-G), (G-K), (K-Z)

RJ Reiter, SD Paredes, A Korkmaz, M-J Jou, D-X Tan
Melatonin combats molecular terrorism at the mitochondrial level

J Mizerovská, H Dračínská, VM Arlt, J Hudeček, P Hodek, HH Schmeiser, E Frei, M Stiborovár
Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone

L Bořek-Dohalská, P Hodek, J Hudeček, M Stiborová
Experimental approaches to evaluate activities of cytochromes P450 3A

D Aimová, J Poljaková, V Kotrbová, M Moserová, E Frei, VM Arlt, M Stiborová
Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2

M Havelková, T Randák, J Blahová, I Slatinská, Z Svobodová
Biochemical markers for the assessment of aquatic environment contamination

M Svobodová, H Dračínská, M Martínková, J Hudeček, P Hodek, E Frei, M Stiborová
Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 – similarity between human and rat enzymes

J Poljaková, T Eckschlager, J Hřebačková, J Hraběta, M Stiborová
The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cells

B Mrázová, M Martínková, V Martínek, E Frei, M Stiborová
Optimization of preparation of apo-cytochrome b5 utilizing apo-myoglobin

J Buchancová, H Poláček, H Hudečková, L Murajda, O Osina, J Valachová
Skeletal fluorosis from the point of view of an occupational exposure to fluorides in former Czechoslovakia

M Vojtíšek, J Patková, J Knotková, L Kašparová, M Hornychová, E Frantík, J Formánek, E Švandová
Metals – impact and implications

P Doleželová, S Mácová, V Pištěková, Z Svobodová, I Bedáňová, E Voslářová
Comparison of the sensitivity of Danio rerio and Poecilia reticulata to silver nitrate in short-term tests

W Aktar, D Sengupta, S Purkait, M Ganguly, M Paramasivam
Degradation dynamics and dissipation kinetics of an imidazole fungicide (Prochloraz) in aqueous medium of varying pH

M Dubovický, P Kovačovský, E Ujházy, J Navarová, I Brucknerová, M Mach
Evaluation of developmental neurotoxicity: some important issues focused on neurobehavioral development

I Brucknerová, E Ujházy, M Dubovický, M Mach
Early assessment of the severity of asphyxia in term newborns using parameters of blood count

J Králová, M Pekarová, K Drábiková, V Jančinová, R Nosáľ, M Číž, A Lojek
The effects of dithiaden on nitric oxide production by RAW 264.7 cells

K Naiman, H Dračínská, M Dračínský, M Martínková, V Martínek, P Hodek, M Štícha, E Frei, M Stiborová
Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole

L Vilímková, J Páca Jr, V Kremláčková, J Páca, M Stiborová
Isolation of cytoplasmic NADPH-dependent phenol hydroxylase and catechol-1,2-dioxygenase from Candida tropicalis yeast

W Aktar, D Sengupta, S Purkait, A Chowdhury
Vertical migration of some herbicides through undisturbed and homogenized soil columns

A Korkmaz, H Yaren, Z I Kunak, B Uysal, B Kurt, T Topal, L Kenar, E Ucar, S Oter
Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results

W Aktar, D Sengupta, A Chowdhury
REVIEW: Impact of pesticides use in agriculture: their benefits and hazards

Ľ Mušák, V Poláková, E Halašová, O Osina, L Vodičková, J Buchancová, H Hudečková, P Vodička
Effect of occupational exposure to cytostatics and nucleotide excision repair polymorphism on chromosomal aberrations frequency

B Payal, HP Kaur, DV Rai
New insight into the effects of lead modulation on antioxidant defense mechanism and trace element concentration in rat bone

M Stiborová, K Naiman, M Martínková, V Martínek, M Svobodová, HH Schmeiser, E Frei
Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA

M Mach, M Dubovický, J Navarová, I Brucknerová, E Ujházy
REVIEW: Experimental modeling of hypoxia in pregnancy and early postnatal life

L Bláha, P Babica, B Maršálek
Toxins produced in cyanobacterial water blooms – toxicity and risks

R Čihák
REACH – an overview

P Dvořák, M Žďárský, K Beňová
Possibilities of alternative generation II biotests at Artemia

H Modrá, Z Svobodová
Incidence of animal poisoning cases in the Czech Republic: current situation

M Pohanka
Cholinesterase based amperometric biosensors for assay of anticholinergic compounds

P Suchý, E Straková, I Herzig, J Staňa, R Kalusová, M Pospíchalová
Toxicological risk of melamine and cyanuric acid in food and feed

J Květina
LETTER TO THE EDITOR: Reflections on changes in biomedical research ethics

14th Interdisciplinary Toxicology Conference
TOXCON 2009: Programme & Abstracts

N Kovalkovičová, I Šutiaková, J Pistl and V Šutiak
Some food toxic for pets

J Kovářová and Z Svobodová
Can thiol compounds be used as biomarkers of aquatic ecosystem contamination by cadmium?

M Tichý and M Rucki
Validation of QSAR models for legislative purposes

R Sabo, L Sabová and J Legáth
The use of parasites as bioindicators of pesticide exposure

Ľ Mušák, E Halašová, T Matáková, L Letková, L Vodičková, J Buchancová, H Hudečková, O Osina, P Souček and P Vodička
Comparison of chromosomal aberrations frequency and polymorphism of GSTs genes in workers occupationally exposed to cytostatics or anaesthetics

M Stiborová, V Martínek, M Semanská, P Hodek, M Dračínský, J Cvačka, HH Schmeiser and E Frei
Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study

J Křížková, K Burdová, M Stiborová, V Křen and P Hodek
The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine

J Hřebačková, J Poljaková, T Eckschlager, J Hraběta, P Procházka, S Smutný and M Stiborová
Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells

E Miadoková
REVIEW: Isoflavonoids – an overview of their biological activities and potential health benefits

A Korkmaz, S Oter, M Seyrek, T Topal
REVIEW: Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity

L Šoltés and G Kogan
REVIEW: Catabolism of hyaluronan: involvement of transition metals

M Moserová, V Kotrbová, D Aimová, M Šulc, E Frei, M Stiborová
Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method

E-J Yang, E-Y Yim, G Song, G-O Kim, C-G Hyun
Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts

S Bandyopadhyay and PP Choudhury
Leaching behaviour of pendimethalin causes toxicity towards different cultivars of Brassica juncea and Brassica campestris in sandy loam soil

P Sadighara, J Ashrafihelan, A Barin, TA Esfahani
Histopathology and cholinergic assessment of Pterocarya fraxinifolia on chicken embryo

M Mach
Editorial

Z Kyselova
REVIEW: Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats

H Astroug, R Simeonova, LV Kassabova, N Danchev, D Svinarov
Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits

R Simeonova, V Vitcheva, M Mitcheva
Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats

K Valachová, G Kogan, P Gemeiner, L Šoltés
Protective effects of manganese(II) chloride on hyaluronan degradation by oxidative system ascorbate plus cupric chloride

MA Çetinkaya, E Baydan
PInvestigation of in vitro effects of ethephon and chlorpyrifos, either alone or in combination, on rat intestinal muscle contraction

M Mach
Editorial

J Navarova and E Ujhazy
Obituary for Prof. Helena Rašková, MD., DSc., Dr.h.c.

V Bauer
In memory of Prof. Helena Rašková, MD., DSc., Dr.h.c.

M Stiborová, J Poljakova, T Eckschlager, R Kizek and E Frei
REVIEW: DNA and histone deacetylases as targets for neuroblastoma treatment

J Kvetina, JE Varayil, SM Ali, M Kunes, J Bures, I Tacheci, S Rejchrt, M Kopacova
REVIEW: Preclinical electrogastrography in experimental pigs

M Dubovicky
REVIEW: Neurobehavioral manifestations of developmental impairment of the brain

V Eybl, D Kotyzova
Protective effect of manganese in cadmium-induced hepatic oxidative damage, changes in cadmium distribution and trace elements level in mice

M Tichy, R Valigurova, R Cabala, R Uzlova, M Rucki
Toxicity of perfluorinated carboxylic acids for aquatic organisms

L Bartosikova, J Necas, T Bartosik, M Pavlik, P Frana
Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats

S Chen, A Vieira
A meta-analysis of medicinal plants to assess the evidence for toxicity

M Mach
Editorial

I Raška
LETTER TO EDITOR: Importance of molecular cell biology investigations in human medicine in the story of the Hutchinson-Gilford progeria syndrome

P Sobrova, V Adam, A Vasatkova, M Beklova, L Zeman, R Kizek
REVIEW: Deoxynivalenol and its toxicity

Teresa Wlasow, Krystyna Demska-Zakes, Piotr Gomulka, Sylwia Jarmolowicz
REVIEW: Various aspects of piscine toxicology

Viera Nosáľová, Ružena Sotníková, Katarína Drábiková, Silvia Fialová, Daniela Košťálová, Silvia Banášová, Jana Navarová
Chemiluminescence response induced by mesenteric ischaemia/reperfusion: effect of antioxidative compounds ex vivo

TOXCON 2010: Borderless Toxicology
Programme

TOXCON 2010: Borderless Toxicology
Abstract Book A-C

TOXCON 2010: Borderless Toxicology
Abstract Book D-M

TOXCON 2010: Borderless Toxicology
Abstract Book M-R

TOXCON 2010: Borderless Toxicology
Abstract Book R-Z

Angelika Puzserova, Iveta Bernatova
Chronic social stress increases nitric oxide-dependent vasorelaxation in normotensive rats

François-Xavier Lesage, Frédèric Deschamps, Hervé Millart
Lead levels in fur of rats treated with inorganic lead measured by inductively coupled argon plasma mass spectrometry

Zdenka Gáspárová, Oľga Ondrejičková, Alena Gajdošíková, Andrej Gajdošík, Vladimír Šnirc, Svorad Štolc
Oxidative stress induced by the Fe2+/ascorbic acid system or model ischemia in vitro: effect of carvedilol and pyridoindole antioxidant SMe1EC2 in young and adult rat brain tissue

Rajamanickam Vinodhini
Detoxifying effect of Nelumbo nucifera and Aegle marmelos on hematological parameters of Common Carp (Cyprinus carpio L.)

Petronela Žižková, Jana Viskupičová, Ľubica Horáková
Pycnogenol® and Ginkgo biloba extract: effect on peroxynitrite-oxidized sarcoplasmic reticulum Ca2+-ATPase

Miloň Tichý, Marián Rucki, Zdeněk Roth, Iveta Hanzlíková, Alena Vlková, Jana Tumová, Rút Uzlová
Extrapolation of toxic indices among test objects

Hana Střítecká, Pavol Hlubik
Selenium, zinc and magnesium: serum levels in members of the Czech Republic rescue fire brigade

Michal DUBOVICKÝ
Editorial

Juraj HARMATHA, Zdeněk ZÍDEK, Eva KMONÍČKOVÁ, Jan ŠMIDRKAL
REVIEW: Immunobiological properties of selected natural and chemically modified phenylpropanoids

Viera JANČINOVÁ, Tomáš PEREČKO, Radomír NOSÁĽ, Danica MIHALOVÁ, Katarína BAUEROVÁ, Katarína DRÁBIKOVÁ
Pharmacological regulation of neutrophil activity and apoptosis. Contribution to new strategy for modulation of inflammatory processes

Antonin LOJEK, Milan ČÍŽ, Michaela PEKAROVÁ, Gabriela AMBROŽOVÁ, Ondřej VAŠÍČEK, Jana MORAVCOVÁ, Lukáš KUBALA, Katarína DRÁBIKOVÁ, Viera JANČINOVÁ, Tomáš PEREČKO, Jana PEČIVOVÁ, Tatiana MAČIČKOVÁ, Radomír NOSÁĽ
Modulation of metabolic activity of phagocytes by antihistamines

Ružena SOTNÍKOVÁ, Jana NEDELČEVOVÁ, Jana NAVAROVÁ, Viera NOSÁĽOVÁ, Katarína DRÁBIKOVÁ, Katalin SZÖCS, Peter KŘENEK, Zuzana KYSEĽOVÁ, Štefan BEZEK, Vladimír KNEZL, Ján DŘÍMAL, Zuzana BROSKOVÁ, Viera KRISTOVÁ, Ľudmila OKRUHLICOVÁ, Iveta BERNÁTOVÁ, Viktor BAUER
REVIEW: Protection of the vascular endothelium in experimental situations

Soňa FRAŇOVÁ, Anna STRAPKOVÁ, Juraj MOKRÝ, Martina ŠUTOVSKÁ, Marta JOŠKOVÁ, Vladimíra SADLOŇOVÁ, Martina ANTOŠOVÁ, Darina PAVELČÍKOVÁ, Dana FLEŠKOVÁ, Gabriela NOSÁĽOVÁ
REVIEW: Pharmacologic modulation of experimentally induced allergic asthma

Katarína BAUEROVÁ, Silvester PONIŠT, Danica MIHALOVÁ, František DRÁFI, Viera KUNCÍROVÁ
Utilization of adjuvant arthritis model for evaluation of new approaches in rheumatoid arthritis therapy focused on regulation of immune processes and oxidative stress

Viera KRISTOVÁ, Milan KRIŠKA, Róbert VOJTKO, Miriam PETROVÁ, Silvia LÍŠKOVÁ, Radoslav VILLÁRIS, Zoltán VARGA, Martin WAWRUCH
REVIEW: Trends in vascular pharmacology research in the Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Bratislava

Eduard UJHÁZY, Mojmír MACH, Jana NAVAROVÁ, Ingrid BRUCKNEROVÁ, Michal DUBOVICKÝ
Safety assessment of the pyridoindole derivative SMe1EC2: developmental neurotoxicity study in rats

Svorad ŠTOLC, Lucia JAKUBÍKOVÁ, Ivica KUKUROVÁ
Body distribution of 11C-methionine and 18FDG in rat measured by microPET

Zdenka GÁSPÁROVÁ, Vladimír ŠNIRC, Svorad ŠTOLC
The new pyridoindole antioxidant SMe1EC2 and its intervention in hypoxia/hypoglycemia-induced impairment of longterm potentiation in rat hippocampus

Jana KOPINCOVÁ, Angelika PÚZSEROVÁ, Iveta BERNÁTOVÁ
REVIEW: Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide

Milan STEFEK
REVIEW: Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract

Galia ZAMARATSKAIA, Martin Krøyer RASMUSSEN, Isabelle HERBIN, Bo EKSTRAND, Vladimir ZLABEK
In vitro inhibition of porcine cytochrome P450 by 17β -estradiol and 17α-estradiol

Ivana HALUZOVÁ, Helena MODRÁ, Jana BLAHOVÁ, Marcela HAVELKOVÁ, Zuzana ŠIROKÁ, Zdeňka SVOBODOVÁ
Biochemical markers of contamination in fish toxicity tests

Anand A. ZANWAR, Mahabaleshwar V. HEGDE, Subhash L. BODHANKAR
Cardioprotective activity of flax lignan concentrate extracted from seeds of Linum usitatissimum in isoprenalin induced myocardial necrosis in rats

Marie STIBOROVÁ, Jitka POLJAKOVÁ, Eva MARTÍNKOVÁ, Lucie BOŘEK-DOHALSKÁ, Tomáš ECKSCHLAGER, Rene KIZEK, Eva FREI
Ellipticine cytotoxicity to cancer cell lines – a comparative study

TOXCON 2011 - Praha, Czech Republic
Abstract Book

Helena KANDÁROVÁ, Silvia LETAŠIOVÁ
REVIEW: Alternative methods in toxicology: pre-validated and validated methods

Ľubica HORÁKOVÁ
REVIEW: Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

Areeba AHMAD, Ravish FATIMA, Veena MAHESHWARI, Riaz AHMAD
Effect of N'-nitrosodimethylamine on red blood cell rheology and proteomic profiles of brain in male albino rats

Ghada E. ELMESALLAMY, Marwa A. ABASS, Nahla A.G. Ahmed REFAT, Amal H. ATTA
Differential effects of alprazolam and clonazepam on the immune system and blood vessels of non-stressed and stressed adult male albino rats

Ashraf S. ALIAS, Muna H. I. AL-ZUBAIDY, Yaareb J. MOUSA, Fouad K. MOHAMMAD
Plasma and whole brain cholinesterase activities in three wild bird species in Mosul, IRAQ: In vitro inhibition by insecticides

Adriana SANTI, Charlene MENEZES, Marta Maria F. DUARTE, Jossiele LEITEMPERGER, Thais LÓPES, Vania L. LORO
Oxidative stress biomarkers and acetylcholinesterase activity in human erythrocytes exposed to clomazone (in vitro)

Katarína WACHALOVÁ, Jana VLKOVIČOVÁ, Veronika JAVORKOVÁ, Lucia MÉZEŠOVÁ, Peter TAKÁČ, Milan KOZÁNEK, Milan LABUDA, Patricia A. NUTTALL, Norbert VRBJAR
Effect of saliva from horse fly Hybomitra bimaculata on kinetic properties of Na,K-ATPase: possible role in regulation of relaxation

Vineet KUMAR, Gulshan ARA, Mohammad AFZAL, Yasir Hasan SIDDIQUE
Effect of methyl methanesulfonate on hsp70 expression and tissue damage in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9